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New USP Guidance on Heat Sanitization: Keep Temperatures Below 80°C

USP concurs: SnowPure’s experience says that heat sanitization should be between 72-80°C: Heat kills most bacteria at 60°C, and kills essentially all bacterial above 65°C. Two common protocols have emerged for sanitizing validated high purity water systems: 72°C for 30-60 minutes (bacteria killed in seconds) 80°C for 15-30 minutes (bacteria killed in milliseconds) SnowPure’s HTS … Read more

Heat Sanitization Basics for Ultrapure and Pharmaceutical Water

Hot water sanitization of EDI is important for Ultrapure Pharmaceutical Water. Even small numbers of bacteria are a problem for critical water systems like pharmaceutical USP water, dialysis water, and ultrapure water for semiconductor manufacturing. Bacteria are often killed with UV-254, chemicals, and heat. Chemical sanitization is often undesirable or prohibited, creating a steady change-over to pure water systems … Read more