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Heat Sanitization Basics for Ultrapure and Pharmaceutical Water

Heat Sanitization Basics for Ultrapure & Pharmaceutical WaterEven small numbers of bacteria are a problem for critical water systems like pharmaceutical USP water, dialysis water, and ultrapure water for semiconductor manufacturing. Bacteria are often killed with UV-254, chemicals, and heat. Chemical sanitization is often undesirable or prohibited, creating a steady change-over to pure water systems that can be sanitized with heat.

Most bacteria are killed at 50-60°C, and essentially all bacteria are killed above 65°C.

Two common protocols have emerged for validated high purity water systems:

72°C for 30-60 minutes (bacteria actually killed in < 0.1 second at 72°C)
80°C for 15-30 minutes (bacteria actually killed in < 0.001 second at 80°C)

Both protocols are effective at killing all bacteria (except for strains of temperature-loving ‘thermophile’ bacteria, which is a long topic in itself).

Therefore, it is important for all components of pure water systems, like the Electropure™ HTS electrodeionization modules, to be stable for multiple cycles well above 80°C.

Enhanced HTS Electrodeionization Features:

  • Hot Water Sanitizable at 84°C / 184°FHeat Sanitization Basics for Ultrapure and Pharmaceutical Water
  • Rapid Heat/Cool Cycle
  • New High Temperature FDA Urethane Materials
  • Sanitize without Chemicals
  • Pharmaceutical Stainless Steel
  • Light & Compact: easy to Ship & Handle

With our improved high-tech FDA-approved urethane material, the Electropure™ EXL and XL-HTS series are stable at high temperatures. The HTS cycle temperature can extend up to 84°C, plenty of headway for either 72°C or 80°C sanitization protocols. And, you can raise the system temperature up more rapidly than ever before. Call for details.